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Mourre Christiane

Christiane Mourre

Laboratoire de Neurosciences Cognitives (LNC - UMR 7291)

Équipe : Cognition et pathophysiologie des ganglions de la base

Aix-Marseille Université - Centre National de la Recherche Scientifique

Centre Saint-Charles, Pole 3C, Case C 3 place Victor Hugo 13331 Marseille cedex 3, FRANCE

Tel : +33 (0) 413-55-08-54 Fax : +33 (0) 413-55-09-58 Email : christiane.mourre@univ-amu.fr

 Intérêts scientifiques majeurs

  • Importance des canaux potassium sur le fonctionnement des réseaux neuronaux impliqués dans les processus mnésiques. Canaux SK, Kv4.
  • Implication des canaux potassium dans la fonction dopaminergique normale et au cours des neuropathologies associées (maladie de Parkinson).
  • Recherche de stratégies thérapeutiques innovantes pour le traitement de la maladie de Parkinson

Approches expérimentales : comportement, pharmacologie, biochimie et biologie moléculaire.

 Diplômes et carrière

  • 1982. Doctorat 3ème cycle Neurosciences - Aix-Marseille III
  • 1987. Doctorat d’Etat ès-Sciences - Nice : "Localisation de canaux ioniques dans le système nerveux central de mammifère".
  • 1983-1994. Assistante puis Maître de Conférences à l’Institut de Pharmacologie Moléculaire et Cellulaire (IPMC), UMR 7275 (Prof. M. Lazdunski) entre le CNRS et l’Université de Nice Sophia Antipolis (UNS).
  • 1994-2011. Directeur de Recherche (2ème classe), UMR6149 (Dr C. Xerri), CNRS - Université de Provence.
  • Depuis 2012. Directeur de Recherche, (2ème classe), UMR7291 (Dr B. Poucet) – CNRS-Aix-Marseille Université (AMU).

 Publications sélectionnées

Liste complète à la fin

1. Aidi-Knani S, Regaya I, Amalric M, Mourre C. Kv4 channel blockade reduces motor and neuropsychiatric symptoms in rodent models of Parkinson’s disease. Behav Pharmacol. 2015, 26(1-2):91-100.

2. Chen L, Deltheil T, Turle-Lorenzo N, Liberge M, Rosier C, Watabe I, Sreng L, Amalric M, Mourre C. SK channel blockade reverses cognitive and motor deficits induced by nigrostriatal dopamine lesions in rats. Int J Neuropsychopharmacol. 2014, 17,295-306.

3. Truchet B, Manrique C, Sreng L, Chaillan FA, Roman FS, Mourre C. Kv4 potassium channels modulate hippocampal EPSP-spike potentiation and spatial memory in rats. Learn Mem. 2012, 19, 282-93.

4. Mpari B, Sreng L, Manrique C, Mourre C. SK(Ca)2 channels transiently downregulated during spatial learning and memory in rats. Hippocampus. 2010, 20, 352-63.

5. Mpari B, Sreng L, Regaya I, Mourre C. Small-conductance Ca(2+)-activated K(+) channels : Heterogeneous affinity in rat brain structures and cognitive modulation by specific blockers. Eur J Pharmacol. 2008, 589, 140-48.

6. Vacher H, Diochot S, Bougis PE, Martin-Eauclaire MF, Mourre C. Kv4 channels sensitive to BmTX3 in rat nervous system : autoradiographic analysis of their distribution during brain ontogenesis. Eur J Neurosci. 2006, 24, 1325-40.

7. Kourrich S, Manrique C, Salin P, Mourre C. Transient hippocampal down-regulation of Kv1.1 subunit mRNA during associative learning in rats. Learn Mem. 2005, 12, 511-9.

8. Kourrich S, Masmejean F, Martin-Eauclaire MF, Soumireu-Mourat B, Mourre C. Inwardly rectifying Kir3.1 subunit knockdown impairs learning and memory in an olfactory associative task in rat. Brain Res Mol Brain Res. 2003, 113, 97-106.

9. Fournier C, Kourrich S, Soumireu-Mourat B, Mourre C. Apamin improves reference memory but not procedural memory in rats by blocking small conductance Ca(2+)-activated K(+) channels in an olfactory discrimination task. Behav Brain Res. 2001, 121, 81-93.

10. Kourrich S, Mourre C, Soumireu-Mourat B. Kaliotoxin, a Kv1.1 and Kv1.3 channel blocker, improves associative learning in rats. Behav Brain Res. 2001, 120, 35-46.

11. Mourre C, Fournier C, Soumireu-Mourat B. Apamin, a blocker of the calcium-activated potassium channel, induces neurodegeneration of Purkinje cells exclusively. Brain Res. 1997, 778, 405-8.

12. Moll C, Mourre C, Lazdunski M, Ulrich J. Increase of sodium channels in demyelinated lesions of multiple sclerosis. Brain Res. 1991, 556, 311-6.

13. Messier C, Mourre C, Bontempi B, Sif J, Lazdunski M, Destrade C. Effect of apamin, a toxin that inhibits Ca(2+)-dependent K+ channels, on learning and memory processes. Brain Res. 1991, 551, 322-6.

14. Mourre C, Widmann C, Lazdunski M. Sulfonylurea binding sites associated with ATP-regulated K+ channels in the central nervous system : autoradiographic analysis of their distribution and ontogenesis, and of their localization in mutant mice cerebellum. Brain Res. 1990, 519, 29-43.

15. Mourre C, Nehlig A, Lazdunski M. Cerebral glucose utilization after administration of apamin, a toxin active on Ca2+-dependent K+ channels. Brain Res. 1988, 451, 274-84.

16. Mourre C, Moll C, Lombet A, Lazdunski M. Distribution of voltage-dependent Na+ channels identified by high-affinity receptors for tetrodotoxin and saxitoxin in rat and human brains : quantitative autoradiographic analysis. Brain Res. 1988, 448, 128-39.

17. Mourre C, Bidard JN, Lazdunski M. High affinity receptors for the bee venom MCD peptide. Quantitative autoradiographic localization at different stages of brain development and relationship with MCD neurotoxicity. Brain Res. 1988, 446, 106-12.

18. Mourre C, Cervera P, Lazdunski M. Autoradiographic analysis in rat brain of the postnatal ontogeny of voltage-dependent Na+ channels, Ca2+-dependent K+ channels and slow Ca2+ channels identified as receptors for tetrodotoxin, apamin and (-)-desmethoxyverapamil. Brain Res. 1987, 417, 21-32.

19. Mourre C, Hugues M, Lazdunski M. Quantitative autoradiographic mapping in rat brain of the receptor of apamin, a polypeptide toxin specific for one class of Ca2+-dependent K+ channels. Brain Res. 1986, 382, 239-49.

20. Mourre C, Lombet A, Lazdunski M. Autoradiographic localization of tetrodotoxin-sensitive Na+ channels in rat brain. Neurosci Lett. 1984, 52, 31-5.

Liste complète