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Séminaire LNC : Ignacio Obeso Martin

Ignacio Obeso Martin

Universitat Oberta de Catalunya

Titre : The role of pre-SMA in cognitive control

Selection of the most appropriate response necessitates inhibition of alternative competing or pre-potent responses. The time it takes to internally stop an ongoing response can be measured with the stop signal reaction time. Inhibition in the stop signal task is associated with activation of the inferior frontal cortex (IFC) and the pre-SMA as well as the subthalamic nucleus and striatum (Aron et al. 2007 ; Duann et al. 2009 ; Li et al. 2008). But also during conflict resolution, elicited by a stop signal that needs to be ignored, similar circuitry has been reported (Aron et al. 2007). Imaging evidence requires further confirmation with transcranial magnetic stimulation (TMS) to verify that the activated areas are causally related to cognitive control. Therefore, during my talk I will present data after applying (i) theta burst stimulation (TBS) pre-SMA and IFG and also (ii) single pulses over pre-SMA to measure the effects produced in behavior and also at the neuronal level using PET. The data will contribute to resolve what processes involved in cognitive control are linked with pre-SMA and IFG functions.