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Accueil du site > Séminaires LNC > séminaires à venir (upcoming seminars)

Philippe Boulinguez

Proactive control of response inhibition : clinical perspectives from recent studies combining multimodal neuroimaging and pharmacological approaches

Most models of inhibitory control are based mainly on the postulate that countermanding inappropriate stimulus driven response impulses rely on phasic, reactive and selective processes triggered by the inappropriate stimulus itself. Here, I review recent studies suggesting that response inhibition also (or rather) relies on tonic, proactive and non-selective processes that are intended to prevent automatic responses to any upcoming stimulus. These findings reveal the paradoxical mechanisms by which voluntary control of action may be achieved. On the one hand, the ability to provide controlled responses in unpredictable environments would require the anticipated implementation of an automatic inhibitory set. On the other hand, enabling automatic behavior when the environment becomes predictable would require top-down control to deactivate temporarily the default inhibitory setting. I will discuss the behavioral, neurofunctional and molecular bases of this mysterious function, which seems essential in several respects. First, these recent advances call for important amendments of the psychophysical methods that are able to evidence this hidden face of executive mechanisms, as they call for critical adaptations of the standard methods used to track related brain activity. Second, they suggest new lines of inquiry for clinical research on a variety of motor/executive symptoms, ranging from akinesia/catatonia to impulsivity.