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Salah El Mestikawy

VGLUT3 and cotransmission in normal and pathological condition

Ecole des Neuroscience Paris Seine

Glutamate is the major excitatory transmitter in the brain. Before its exocytotic release glutamate is accumulated into synpatic vesicles by 3 subtypes of vesicular transporters named : VGLUT1-3. VGLUTs are key functional and anatomical markers of glutamatergic transmission. VGLUT1-3 are highly conserved from a structural and functional point of view. However, they are distributed in almost non-overlaping neuronal populations. VGLUT1 and VGLUT2 are used by cortical and subcortical neurons (respectively). Surprisingly, VGLUT3 is present in neurons using other transmitter than glutamate such as : subpopulations of 5-HT neurons or GABAergic interneurons as well as cholinergic interneurons from the striatum. Our team try to better understand the function of glutamatergic co-transmission in normal and pathological conditions.