Rethinking the Cognitive Mechanisms Underlying Pantomime of Tool Use: Evidence from Alzheimer's Disease and Semantic Dementia.


  • Lesourd Mathieu
  • Baumard Josselin
  • Jarry Christophe
  • Etcharry-Bouyx Frédérique
  • Belliard Serge
  • Moreaud Olivier
  • Croisile Bernard
  • Chauviré Valérie
  • Granjon Marine
  • Le Gall Didier
  • Osiurak François


  • Alzheimer’s disease
  • Apraxia
  • Functional knowledge
  • Manipulation knowledge
  • Mechanical knowledge
  • Pantomime of tool use
  • Semantic dementia

Document type



Pantomiming the use of familiar tools is a central test in the assessment of apraxia. However, surprisingly, the nature of the underlying cognitive mechanisms remains an unresolved issue. The aim of this study is to shed a new light on this issue by exploring the role of functional, mechanical, and manipulation knowledge in patients with Alzheimer's disease and semantic dementia and apraxia of tool use.

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