A prospective behavioral and imaging study exploring the impact on long-term memory of radiotherapy delivered for a brain tumor in childhood and adolescence


  • Baudou Eloïse
  • Pariente Jérémie
  • Péran Patrice
  • Tensaouti Fatima
  • Pollidoro Lisa
  • Meligne Déborah
  • Ducassou Anne
  • Gros-Dagnac Hélène
  • Arribarat Germain
  • Desirat Jean-Pierre
  • Bertozzi Anne-Isabelle
  • Gambart Marion
  • Larrieu-Ciron Delphine
  • Barbolosi Dominique
  • Muracciole Xavier
  • Lemesle Béatrice
  • Sevely Annick
  • Roques Margaux
  • Cazaux Mathilde
  • Tallet Jessica
  • Danna Jeremy
  • Chaix Yves
  • Laprie Anne


  • CMS
  • Children's Memory Scale
  • DFA
  • Discriminating factor analysis
  • DTI
  • Diffusion tensor imaging
  • IQ
  • Intellectual quotient
  • Wechsler Memory Scale
  • Magnetic resonance imaging
  • Memory
  • NTCP
  • Normal tissue complication probability
  • PFT
  • Posterior fossa tumor
  • Posterior fossa brain tumor
  • Radiotherapy
  • SRTT
  • Serial reaction time task
  • Spectroscopy
  • TCP
  • Tumor control probability
  • WAIS
  • Wechsler Adult Intelligence Scale
  • WISC
  • Wechsler Intelligence Scale for Children
  • Pseudocontinuous arterial spin labeling
  • Rs-fMRI
  • Resting-state functional magnetic resonance imaging
  • 3DT1
  • T1-weighted imaging

document type



Posterior fossa tumors represent two thirds of brain tumors in children. Although progress in treatment has improved survival rates over the past few years, long-term memory impairments in survivors are frequent and have an impact on academic achievement. The hippocampi, cerebellum and cerebellar-cortical networks play a role in several memory systems. They are affected not only by the location of the tumor itself and its surgical removal, but also by the supratentorial effects of complementary treatments, particularly radiotherapy. The IMPALA study will investigate the impact of irradiation doses on brain structures involved in memory, especially the hippocampi and cerebellum.

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