COSTE Bertrand
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Equipe(s) de recherche
Bases neurales de la somatosensation
Domaines de recherche
Bertrand Coste Research is funded from the European Research Council/ERC Grant Agreement n. 678610.
Mechanosensation refers to our ability to perceive touch, pain and proprioception through our somatosensory system, constituting with vision, olfaction and hearing the crucial senses governing our perception of surrounding environment and our social interactions. Mechanosensation relies on mechanotransduction, the signaling by which external mechanical stimuli are converted into biological signals within the cell. Molecular mechanosensors of the somato-sensory system are mechanically-activated ion channels, which identification constitutes one of the most important challenges in the field of sensory transduction. Our goal is to characterize mechanosensation from molecular to behavior levels.
Publications
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- Patrick Delmas, Thibaud Parpaite, Bertrand Coste. PIEZO channels and newcomers in the mammalian mechanosensitive ion channel family. Neuron, 2022, ⟨10.1016/j.neuron.2022.07.001⟩. ⟨hal-03744177⟩
- Bertrand Coste. Prix Nobel de physiologie ou médecine 2021 : Les senseurs de la température et du toucher. Médecine/Sciences, 2022, 38 (1), pp.96-98. ⟨10.1051/medsci/2021248⟩. ⟨hal-03539698⟩
- Angélique Desplat, Virginie Penalba, Emeline Gros, Thibaud Parpaite, Bertrand Coste, et al.. Piezo1–Pannexin1 complex couples force detection to ATP secretion in cholangiocytes. Journal of General Physiology, 2021, 153 (12), ⟨10.1085/jgp.202112871⟩. ⟨hal-03420422⟩
- Thibaud Parpaite, Lucie Brosse, Nina Séjourné, Amandine Laur, Yasmine Mechioukhi, et al.. Patch-seq of mouse DRG neurons reveals candidate genes for specific mechanosensory functions. Cell Reports, 2021, 37 (5), pp.109914. ⟨10.1016/j.celrep.2021.109914⟩. ⟨hal-03464549⟩
- Evie Kritioti, Athina Theodosiou, Thibaud Parpaite, Angelos Alexandrou, Nayia Nicolaou, et al.. Unravelling the genetic causes of multiple malformation syndromes: A whole exome sequencing study of the Cypriot population. PLoS ONE, 2021, 16 (7), pp.e0253562. ⟨10.1371/journal.pone.0253562⟩. ⟨hal-03396027⟩
- Patrick Delmas, Bertrand Coste. SnapShot: Orofacial Sensation. Cell, 2020, 183 (1), pp.284-284.e1. ⟨10.1016/j.cell.2020.08.014⟩. ⟨hal-03011779⟩
- Patrick Delmas, Sergiy M Korogod, Bertrand Coste. Noxious Mechanosensation. The Oxford Handbook of the Neurobiology of Pain, pp.1-41, 2019, ⟨10.1093/oxfordhb/9780190860509.013.14⟩. ⟨hal-02346216⟩
- Yuanquan Song, Dan Li, Olivia Farrelly, Leann Miles, Feng Li, et al.. The Mechanosensitive Ion Channel Piezo Inhibits Axon Regeneration. Neuron, 2019, 102 (2), pp.373-389.e6. ⟨10.1016/j.neuron.2019.01.050⟩. ⟨hal-02553101⟩
- Thibaud Parpaite, Bertrand Coste. Piezo channels. Current Biology - CB, 2017, 27 (7), pp.R250-R252. ⟨10.1016/j.cub.2017.01.048⟩. ⟨hal-01765081⟩
- Adrienne E. Dubin, Swetha Murthy, Amanda H. Lewis, Lucie Brosse, Stuart M. Cahalan, et al.. Endogenous Piezo1 Can Confound Mechanically Activated Channel Identification and Characterization. Neuron, 2017, 94 (2), pp.266+. ⟨10.1016/j.neuron.2017.03.039⟩. ⟨hal-01765080⟩
- Zizhen Wu, Nicolas Grillet, Bo Zhao, Christopher Cunningham, Sarah Harkins-Perry, et al.. Mechanosensory hair cells express two molecularly distinct mechanotransduction channels. Nature Neuroscience, 2016, 20 (1), pp.24--33. ⟨10.1038/nn.4449⟩. ⟨hal-01473985⟩
- Bertrand Coste, Swetha Murthy, Jayanti Mathur, Manuela Schmidt, Yasmine Mechioukhi, et al.. Piezo1 ion channel pore properties are dictated by C-terminal region. Nature Communications, 2015, 6 (1), ⟨10.1038/ncomms8223⟩. ⟨hal-01787362⟩
- Ruhma Syeda, Jie Xu, Adrienne Dubin, Bertrand Coste, Jayanti Mathur, et al.. Chemical activation of the mechanotransduction channel Piezo1. eLife, 2015, 4, ⟨10.7554/eLife.07369⟩. ⟨hal-03464372⟩
- Linda Volkers, Yasmine Mechioukhi, Bertrand Coste. Piezo channels: from structure to function.. Pflügers Archiv European Journal of Physiology, 2014, 467 (1), pp.95-9. ⟨hal-01188641⟩
- Patrick Delmas, Bertrand Coste, Eric Honoré. A special issue on physiological aspects of mechanosensing.. Pflügers Archiv European Journal of Physiology, 2014, 467 (1), pp.1-2. ⟨hal-01176940⟩
- Sanjeev Ranade, Seung-Hyun Woo, Adrienne Dubin, Rabih Moshourab, Christiane Wetzel, et al.. Piezo2 is the major transducer of mechanical forces for touch sensation in mice. Nature, 2014, 516 (7529), pp.121-125. ⟨10.1038/nature13980⟩. ⟨hal-03464375⟩
- S. Ranade, Z. Qiu, S.-H. Woo, S. Hur, S. Murthy, et al.. Piezo1, a mechanically activated ion channel, is required for vascular development in mice. Proceedings of the National Academy of Sciences of the United States of America, 2014, 111 (28), pp.10347-10352. ⟨10.1073/pnas.1409233111⟩. ⟨hal-03464379⟩
- Patrick Delmas, Bertrand Coste. Mechano-Gated Ion Channels in Sensory Systems. Cell, 2013, 155 (2), pp.278-284. ⟨10.1016/j.cell.2013.09.026⟩. ⟨hal-03464381⟩
- Bertrand Coste, G. Houge, M. Murray, N. Stitziel, M. Bandell, et al.. Gain-of-function mutations in the mechanically activated ion channel PIEZO2 cause a subtype of Distal Arthrogryposis. Proceedings of the National Academy of Sciences of the United States of America, 2013, 110 (12), pp.4667-4672. ⟨10.1073/pnas.1221400110⟩. ⟨hal-03464424⟩
- Juliette Albuisson, Swetha E Murthy, Michael Bandell, Bertrand Coste, Hélène Louis-Dit-Picard, et al.. Dehydrated hereditary stomatocytosis linked to gain-of-function mutations in mechanically activated PIEZO1 ion channels. Nature Communications, 2013, 4 (1), pp.1884. ⟨10.1038/ncomms2899⟩. ⟨hal-01532097⟩
- Jizhe Hao, Jérôme Ruel, Bertrand Coste, Yann Roudaut, Marcel Crest, et al.. Piezo-electrically driven mechanical stimulation of sensory neurons.. Methods in Molecular Biology, 2013, 998, pp.159-70. ⟨10.1007/978-1-62703-351-0_12⟩. ⟨hal-00855019⟩
- Adrienne e. Dubin, Manuela Schmidt, Jayanti Mathur, Matthew j. Petrus, Bailong Xiao, et al.. Inflammatory Signals Enhance Piezo2-Mediated Mechanosensitive Currents. Cell Reports, 2012, 2 (3), pp.511-517. ⟨10.1016/j.celrep.2012.07.014⟩. ⟨hal-03464409⟩
- Sung Eun Kim, Bertrand Coste, Abhishek Chadha, Boaz Cook, Ardem Patapoutian. The role of Drosophila Piezo in mechanical nociception. Nature, 2012, 483 (7388), pp.209-212. ⟨10.1038/nature10801⟩. ⟨hal-03464378⟩
- Bertrand Coste, Bailong Xiao, Jose Santos, Ruhma Syeda, Jörg Grandl, et al.. Piezo proteins are pore-forming subunits of mechanically activated channels. Nature, 2012, 483 (7388), pp.176-181. ⟨10.1038/nature10812⟩. ⟨hal-03464354⟩
- Bailong Xiao, Bertrand Coste, Jayanti Mathur, Ardem Patapoutian. Temperature-dependent STIM1 activation induces Ca2+ influx and modulates gene expression. Nature Chemical Biology, 2011, 7 (6), pp.351-358. ⟨10.1038/nchembio.558⟩. ⟨hal-03464419⟩
- Bertrand Coste, Jayanti Mathur, Manuela Schmidt, Taryn Earley, Sanjeev Ranade, et al.. Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels. Science, 2010, 330 (6000), pp.55-60. ⟨10.1126/science.1193270⟩. ⟨hal-03464348⟩
- François Maingret, Bertrand Coste, Françoise Padilla, Nadine Clerc, Marcel Crest, et al.. Inflammatory mediators increase Nav1.9 current and excitability in nociceptors through a coincident detection mechanism.. Journal of General Physiology, 2008, 131 (3), pp.211-25. ⟨10.1085/jgp.200709935⟩. ⟨hal-00274301⟩
- Françoise Padilla, Marie-Lise Couble, Bertrand Coste, François Maingret, Nadine Clerc, et al.. Expression and localization of the Nav1.9 sodium channel in enteric neurons and in trigeminal sensory endings: implication for intestinal reflex function and orofacial pain.. Molecular and Cellular Neuroscience, 2007, 35 (1), pp.138-52. ⟨10.1016/j.mcn.2007.02.008⟩. ⟨hal-00170428⟩
- Bertrand Coste, Marcel Crest, Patrick Delmas. Pharmacological dissection and distribution of NaN/Nav1.9, T-type Ca2+ currents, and mechanically activated cation currents in different populations of DRG neurons.. Journal of General Physiology, 2007, 129 (1), pp.57-77. ⟨10.1085/jgp.200609665⟩. ⟨hal-00131512⟩
- Aurélie Giamarchi, Françoise Padilla, Bertrand Coste, Matthieu Raoux, Marcel Crest, et al.. The versatile nature of the calcium‐permeable cation channel TRPP2. EMBO Reports, 2006, 7 (8), pp.787-793. ⟨10.1038/sj.embor.7400745⟩. ⟨hal-04010467⟩
