JACOB Pierre-yves
Primary tabs
Equipe(s) de recherche
Localisation
Domaines de recherche
The aim of my research is to understand how the brain codes for information that serves complex cognitive operations of explicit learning, memory processes and spatial navigation.
During my thesis, I used both in vivo electrophysiological and behavioural approaches in rodents to investigate the nature of spatial representation formed by the medial entorhinal cortex, a brain structure involved in spatial memory and containing grid cells, head direction cells and conjunctive cells. Using the same methods during my postdoc in the Jeffery lab, I provided some new understanding of the head direction signal in both cortical and subcortical structures: the retrosplenial cortex, the postsubiculum and the anterodorso thalamic nucleus. In particular, I shown how external information provided by visual landmarks, self motion information, and contextual information, are integrated to signal the head direction activity.
Back to the LNC spatial cognition team in Marseille, I am currently attempting to understand the function of the bidirectional cells (also called flip cells) I discovered in Jeffery lab, and how they interact with other spatial neurons, grid and place cells. My research is funded by the f, the Agence Nationale de la Recherche (ANR), the Centre National de la Recherche Scientifique (CNRS) and Aix-Marseille University (AMU).
Enseignements
ATER (temporary teaching and research assistant) in Aix-Marseille University from September 2017 to Mars 2018. Classes in "Development and plasticity of the central nervous system", "Physiological basis of cardiavascular and respiratory system" and "Physiological basis of sensori-motor system" 2d and 3rd year of Biology and Neuroscience.
December 2015-2016-2017-2018-2019-2020-2021: "Neuroanatomical basis of spatial navigation" lectures, Master 2 Pierre and Marie Cury University, Paris.
Publications
- Nada El Mahmoudi, Célia Laurent, David Péricat, Isabelle Watabe, Agnès Lapotre, et al.. Long-lasting spatial memory deficits and impaired hippocampal plasticity following unilateral vestibular loss. Progress in Neurobiology, 2023, 223, pp.102403. ⟨10.1016/j.pneurobio.2023.102403⟩. ⟨hal-04086813⟩
- Joanna Sikora, Sonia Di Bisceglie Caballero, David Reiss, Brigitte Kieffer, Pierre Paoletti, et al.. Zn2+ inhibits spatial memory and hippocampal place cell representation through high-affinity binding to the NMDA receptor GluN2A subunit. iScience, 2022, 25 (11), pp.105355. ⟨10.1016/j.isci.2022.105355⟩. ⟨hal-03832486⟩
- Pierre-Yves Jacob, Tiffany van Cauter, Bruno Poucet, Francesca Sargolini, Etienne Save. Medial entorhinal cortex lesions induce degradation of CA1 place cell firing stability when self-motion information is used. Brain and Neuroscience Advances, 2020, 4, pp.239821282095300. ⟨10.1177/2398212820953004⟩. ⟨hal-02955314⟩
- Cameron Meyer-Mueller, Pierre-Yves Jacob, Jean-Yves Montenay, Julien Poitreau, Franck A Chaillan, et al.. Dorsal, but not ventral, hippocampal inactivation alters deliberation in rats. Behavioural Brain Research, 2020, ⟨10.1016/j.bbr.2020.112622⟩. ⟨hal-02640533⟩
- Pierre-Yves Jacob, Fabrizio Capitano, Bruno Poucet, Etienne Save, Francesca Sargolini. Path integration maintains spatial periodicity of grid cell firing in a 1D circular track. Nature Communications, 2019, 10 (1), ⟨10.1038/s41467-019-08795-w⟩. ⟨hal-02025122⟩
- Philippe Gaussier, Jean Paul Banquet, Nicolas Cuperlier, Mathias Quoy, Lise Aubin, et al.. Merging information in the entorhinal cortex: what can we learn from robotics experiments and modeling?. Journal of Experimental Biology, 2019, 222 (Suppl 1), pp.jeb186932. ⟨10.1242/jeb.186932⟩. ⟨hal-02042385⟩
- Pierre-Yves Jacob, Marta Gordillo-Salas, Justine Facchini, Bruno Poucet, Etienne Save, et al.. Medial entorhinal cortex and medial septum contribute to self-motion-based linear distance estimation. Brain Structure and Function, 2017, 222 (6), pp.2727 - 2742. ⟨10.1007/s00429-017-1368-4⟩. ⟨hal-01664365⟩
- Yave Roberto Lozano, Hector Page, Pierre-Yves Jacob, Eleonora Lomi, James Street, et al.. Retrosplenial and postsubicular head direction cells compared during visual landmark discrimination. Brain and Neuroscience Advances, 2017, 1, ⟨10.1177/2398212817721859⟩. ⟨hal-01664369⟩
- Pierre-Yves Jacob, Giulio Casali, Laure Spieser, Hector Page, Dorothy Overington, et al.. An independent, landmark-dominated head-direction signal in dysgranular retrosplenial cortex. Nature Neuroscience, 2016, 20 (2), pp.173-175. ⟨10.1038/nn.4465⟩. ⟨hal-01664366v2⟩
- Pierre-Yves Jacob, Bruno Poucet, Martine Liberge, Etienne Save, Francesca Sargolini. Vestibular control of entorhinal cortex activity in spatial navigation. Frontiers in Integrative Neuroscience, 2014, 8, ⟨10.3389/fnint.2014.00038⟩. ⟨hal-01664364⟩
